Modeling the effect of a combinatorial anti-CTLA antibody and radiation therapy on metastatic lung cancer.

Authors

  • Jean-Emmanuel Kouadio Shepherd University
  • Qing Wang Shepherd University

DOI:

https://doi.org/10.55632/pwvas.v92i1.708

Abstract

Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is an inhibitory receptor that is upregulated after T-cell activation, and transmits signals that suppress T-cell activation and proliferation through the depletion of CD8+ T cells.  Antibodies targeting CTLA-4 can selectively deplete regulatory T cells by antibody-mediated cellular cytotoxicity mechanisms. However, anti-CTLA-4 antibody therapy as a single treatment is limited on effectiveness to fight against immunogenic diseases like metastatic cancers. Radiation therapy (RT) on the other hand is a longstanding pillar of cancer treatment, historically utilized to treat a discrete target and provide local tumor control. Recent preclinical studies demonstrated that RT is synergistic with anti-CTLA antibody and induces systemic anti-tumor responses. In order to better understand the effect of the combination therapy on metastatic lung cancer, we developed a mathematical model using a system of impulsive differential equations. The objective of this study was to develop a predictive simulation platform to improve cancer management by manipulating dose and fractionation schedule of RT and dose and timing for the anti-CTLA-4 antibody therapy. This study is supported by NIH Grant P20GM103434 to the West Virginia IDeA Network for Biomedical Research Excellence.

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Published

2020-04-29

How to Cite

Kouadio, J.-E., & Wang, Q. (2020). Modeling the effect of a combinatorial anti-CTLA antibody and radiation therapy on metastatic lung cancer. Proceedings of the West Virginia Academy of Science, 92(1). https://doi.org/10.55632/pwvas.v92i1.708

Issue

Section

Meeting Abstracts-Poster