Synthesis of a rhodium complex bearing a chiral nitrogen-based ligand for asymmetric hydrogenation.
DOI:
https://doi.org/10.55632/pwvas.v88i1.108Abstract
Asymmetric hydrogenation of prochiral molecules by chiral metal complexes has emerged as a useful synthetic tool for the preparation of single enantiomer molecules and has diverse application in a variety of industries, including pharmaceuticals. To date, most catalytic systems for asymmetric hydrogenation are supported by phosphine ligands. Thus, chiral nitrogen-based ligands provide an opportunity to investigate a relatively underexplored area of hydrogenation chemistry. To this end, we are investigating rhodium complexes supported by chiral nitrogen-based ligands. The synthesis of a previously reported chiral nitrogen ligand (R,R)-2,6-bis[1-(N-piperidinyl)ethyl]pyridine has been achieved through a modified synthetic procedure and characterized by NMR spectroscopy. Attempts to synthesize our target rhodium complex in order to investigate asymmetric hydrogenation reactivity are currently underway.Downloads
Published
2016-07-26
How to Cite
Wagoner, K., & Webb, J. (2016). Synthesis of a rhodium complex bearing a chiral nitrogen-based ligand for asymmetric hydrogenation. Proceedings of the West Virginia Academy of Science, 88(1). https://doi.org/10.55632/pwvas.v88i1.108
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Meeting Abstracts-Poster
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