Synthesis of chiral and achiral cobalt complexes for hydrogenation studies.

Authors

  • Darren Queen WV Wesleyan College
  • Joanna Webb West Virginia Wesleyan College

Keywords:

Organometallic chemistry

Abstract

Catalytic hydrogenation reactions have diverse applications in the petrochemical, food, pharmaceutical, and agricultural industries for the efficient synthesis of useful molecules.  Specifically, asymmetric hydrogenation of olefins is a key method in the synthesis of single-enantiomer products necessary for the pharmaceutical industry, in particular. However, precious metals such as ruthenium, rhodium, and iridium are the basis for many of the current catalysts. It would be advantageous to replace these more expensive and toxic metals with first-row transition metals that are abundant and environmentally compatible. In addition, most catalytic systems for asymmetric hydrogenation are supported by phosphine ligands. Thus, chiral nitrogen-based ligands provide an opportunity to investigate a relatively underexplored area of hydrogenation chemistry. To this end, we are pursuing cobalt complexes supported by chiral nitrogen-based ligands. The synthesis of a previously reported chiral nitrogen ligand, (R,R)-2,6-bis[1-(N-piperidinyl)ethyl]pyridine, is underway with characterization by NMR spectroscopy. Upon successful synthesis of the ligand, cobalt complexes will be targeted in order to investigate asymmetric hydrogenation reactivity. In addition, synthesis of cobalt complexes bearing the achiral congener ligand, pip2NNN [pip2NNN = 2,6-bis(piperidylmethyl)pyridine], is underway in order to compare reactivity of chiral versus achiral complexes. 

Author Biography

Joanna Webb, West Virginia Wesleyan College

Assistant Professor 

Department of Chemistry

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Published

2017-04-04

How to Cite

Queen, D., & Webb, J. (2017). Synthesis of chiral and achiral cobalt complexes for hydrogenation studies. Proceedings of the West Virginia Academy of Science, 89(1). Retrieved from https://pwvas.org/index.php/pwvas/article/view/229

Issue

Section

Meeting Abstracts-Poster