Identification of plant extracts with antimicrobial activity against drug-resistant bacteria .

Authors

  • Kéren Lubembo West Liberty University
  • Joseph Horzempa West Liberty University

Keywords:

MRSA, Antibiotic, Pseudomonas, natural products

Abstract

Identification of plant extracts with antimicrobial activity against drug-resistant bacteria. Kéren Lubembo and Joseph Horzempa. Department of Natural Sciences and Mathematics, West Liberty University, West Liberty, WV


Methicillin-resistant Staphylococcus aureus (MRSA) is a drug-resistant opportunistic pathogen that can cause serious infections which may lead to sepsis and even death. We previously identified extracts from 10 plants that exhibited antimicrobial activity toward Pseudomonas aeruginosa – another drug-resistant opportunistic pathogen. The goal of this study was to determine if any of these extracts also exhibited antimicrobial activity against MRSA. Here we
used a disk diffusion assays to measure antibiotic sensitivity. Of the ten extracts tested, only extracts of Agrimonia gryposepala (tall hairy agrimony) produced measureable zones of inhibition. Vancomycin was used as a positive control and produced robust zones of inhibition (as this antibiotic is known to have antimicrobial activity against MRSA; the negative control [vehicle, ethanol] did not produce zones of inhibition). These data suggest that A. gryposepala
extracts may contain a compound that could have broad applicability toward drug-resistant bacteria whereas all other extracts tested exhibited a narrower spectrum of activity. (Supported by NIH Grant P20GM103434 to the West Virginia IDeA Network for Biomedical Research Excellence)

Author Biographies

Kéren Lubembo, West Liberty University

Student at West Liberty University

Joseph Horzempa, West Liberty University

Professor at West Liberty University

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Published

2018-04-02

How to Cite

Lubembo, K., & Horzempa, J. (2018). Identification of plant extracts with antimicrobial activity against drug-resistant bacteria . Proceedings of the West Virginia Academy of Science, 90(1). Retrieved from https://pwvas.org/index.php/pwvas/article/view/343

Issue

Section

Meeting Abstracts-Poster